Synergistic anti-inflammatory activities of a new flavone and other flavonoids from Tephrosia hildebrandtii vatke.

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dc.contributor.author Owor, Richard Oriko
dc.contributor.author Bedane, Kibrom Gebreheiwot
dc.contributor.author Openda, Yolande Ikala
dc.contributor.author Zühlke, Sebastian
dc.contributor.author Derese, Solomon
dc.contributor.author Ong’amo, George
dc.contributor.author Ndakala, Albert
dc.contributor.author Spiteller, Michael
dc.date.accessioned 2022-02-19T09:06:13Z
dc.date.available 2022-02-19T09:06:13Z
dc.date.issued 2020-03-31
dc.identifier.citation Owor, Richard Oriko . . . [et al.] .(2021) Synergistic anti-inflammatory activities of a new flavone and other flavonoids from Tephrosia hildebrandtii vatke, Natural Product Research, 35:22, 4486-4493, DOI: 10.1080/14786419.2020.1736065 en_US
dc.identifier.uri https://doi.org/10.60682/k3cj-8614
dc.description Journal article en_US
dc.description.abstract A new avone, named hilde avone (1) along with 7 other known avonoids were isolated from the aerial parts of Tephrosia hildebrandtii Vatke. Their characterisation was based on NMR and MS data analysis. The anti-in ammatory properties of the crude extract, isolated compounds and combination of the compounds were investigated in lipopolysaccharide (LPS)-stimulated peripheral blood mononuclear cells (PBMCs). Treatment of the LPS-stimulated PBMCs with the isolated avonoids at a concentration of 100 µM signi cantly reduced the production of interleukins (IL1β, IL-2 and IL-6), interferon-gamma (IFN-γ), granulocyte macrophage-colony stimulating factor (GM-CSF) and tumour necrosis factor-alpha (TNF-α). It was also found that the combination of a avone and avanones exhibited remarkable synergistic anti-in ammatory e ects on the production of the cytokines. Keywords: Fabaceae, Tephrosia hildebrandtii, avonoid, anti-in ammatory, hilde avone cytokine synergy en_US
dc.description.sponsorship Busitema University en_US
dc.language.iso en en_US
dc.publisher Taylor & Francis online. en_US
dc.subject Fabaceae en_US
dc.subject Tephrosia hildebrandtii en_US
dc.subject avonoid en_US
dc.subject Anti-in ammatory en_US
dc.subject Hilde avone en_US
dc.subject Cytokine synergy en_US
dc.title Synergistic anti-inflammatory activities of a new flavone and other flavonoids from Tephrosia hildebrandtii vatke. en_US
dc.type Article en_US


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